An inhibitor of Nrf2 (IC50 = 1.9 µM) that blocks downstream target gene expression; substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs

ML-385 – 5 mg

Brand:
Cayman
CAS:
846557-71-9
Storage:
-20
UN-No:
Non-Hazardous - /

ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 µM) that blocks downstream target gene expression.{32646} It substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs.{32646} ML-385 shows specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.{32646}  

 

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Description

An inhibitor of Nrf2 (IC50 = 1.9 µM) that blocks downstream target gene expression; substantially enhances cytotoxicity in non-small cell lung cancer (NSCLC) cells treated with platinum-based drugs

Formal name: N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

Synonyms: 

Molecular weight: 511.6

CAS: 846557-71-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Cancer|Transcription Factors

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