A tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase); reduces melanin content in isolated dark human melanocytes at 1.56 μM; topical administration at 5% induces skin lightening in human skin mouse xenograft models; inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM); induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells at 50 μM; reduces tumor growth in a B16/F10 murine melanoma model at 50 mg/kg

Deoxyarbutin – 250 g

Brand:
Cayman
CAS:
53936-56-4
Storage:
4
UN-No:
Non-Hazardous - /

Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase).{54107} It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM.{54108} Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM).{54109} It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.  

 

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Description

A tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase); reduces melanin content in isolated dark human melanocytes at 1.56 μM; topical administration at 5% induces skin lightening in human skin mouse xenograft models; inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM); induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells at 50 μM; reduces tumor growth in a B16/F10 murine melanoma model at 50 mg/kg

Formal name: 4-[(tetrahydro-2H-pyran-2-yl)oxy]-phenol

Synonyms: 

Molecular weight: 194.2

CAS: 53936-56-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G2/S||Research Area|Cancer|Cell Death|Apoptosis

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