A PDE9 inhibitor and adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 μM

Paraxanthine – 100 mg

Brand:
Cayman
CAS:
611-59-6
Storage:
-20
UN-No:
Non-Hazardous - /

Paraxanthine is an inhibitor of phosphodiesterase 9 (PDE9) and an antagonist of adenosine receptors A1 and A2 (Kis = 35 and 22 μM, respectively in equine forebrain tissues).{38150,38151} It is the main metabolite of caffeine (Item No. 14118) in humans, making up 80% of the three dimethylxanthine metabolites produced by caffeine demethylation.{38150,38152} Paraxanthine increases locomotor activity and counteracts adenosine receptor agonist-induced motor depression in rats not habituated to caffeine.{38150} At a dose of 30 mg/kg, paraxanthine induces a significant increase in striatal cGMP and extracellular striatal dopamine concentrations in vivo. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.{38152}  

 

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Description

A PDE9 inhibitor and adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 μM, respectively in equine forebrain tissues); is the main metabolite of caffeine in humans; increases locomotor activity and counteracts adenosine receptor agonist-induced motor depression in rats not habituated to caffeine; induces a significant increase in striatal cGMP and extracellular striatal dopamine concentrations in vivo; promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety,

Formal name: 3,7-dihydro-1,7-dimethyl-1H-purine-2,6-dione

Synonyms:  1,7-Dimethylxanthine|NSC 400018

Molecular weight: 180.2

CAS: 611-59-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cell Biology|Cell Signaling|cGMP Signaling||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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