An allosteric HDAC3 inhibitor (Ki = 0.16 nM); selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95

HDAC3 Inhibitor – 1 mg

Brand:
Cayman
CAS:
2044701-99-5
Storage:
-20
UN-No:
De Minimis - 1170 / 3

HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM).{32697} It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively).  

 

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Description

An allosteric HDAC3 inhibitor (Ki = 0.16 nM); selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs; selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively),

Formal name: 4-[[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]amino]methyl]-benzoic acid 2-propylhydrazide

Synonyms:  Histone Deacetylase 3

Molecular weight: 337.4

CAS: 2044701-99-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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