A selective

CVT-313 – 5 mg

Brand:
Cayman
CAS:
199986-75-9
Storage:
-20
UN-No:
Non-Hazardous - /

CVT-313 is a competitive inhibitor of cyclin-dependent kinase 2 (Cdk2; IC50 = 0.5 µM in vitro).{32889} It displays 8.5- and 430-fold selectivity for Cdk2 over Cdk1 and Cdk4, respectively, and has no effect on other unrelated ATP-dependent serine/threonine kinases.{32889} CVT-313 induces cell cycle arrest at the G1/S boundary.{32889} CVT-313 is often used as a selective Cdk2 inhibitor, although at some concentrations and in some cells it may also inhibit Cdk1.{32889,32888,32890,23163}  

 

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Description

A selective, competitive inhibitor of Cdk2 (IC50 = 0.5 µM in vitro); induces cell cycle arrest at the G1/S boundary

Formal name: 2,2′-[[6-[[(4-methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis-ethanol

Synonyms:  Cdk2 Inhibitor III|Cyclin-dependent kinase 2 Inhibitor III

Molecular weight: 400.5

CAS: 199986-75-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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