An antitubercular agent; active against M. tuberculosis in vitro (MICs = 0.5-1.56 μM); inhibits DprE1 (IC50 = 32 nM); reduces lung bacterial burden in a mouse model of chronic tuberculosis infection at 300 mg/kg and exhibits a synergistic effect when administered in combination with TMC207

DprE1-IN-2 – 1 mg

Brand:
Cayman
CAS:
1615713-87-5
Storage:
-20
UN-No:
Non-Hazardous - /

DprE1-IN-2 is an antitubercular agent that is active against M. tuberculosis in vitro, with MIC values ranging from 0.5 to 1.56 μM.{32839} It is an inhibitor of decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1; IC50 = 32 nM), an enzyme involved in mycobacterial cell wall biogenesis. DrpE1-IN-2 (300 mg/kg) reduces lung bacterial burden in a mouse model of chronic tuberculosis infection and exhibits a synergistic effect when administered in combination with TMC207 (Item No. 20247).  

 

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Description

An antitubercular agent; active against M. tuberculosis in vitro (MICs = 0.5-1.56 μM); inhibits DprE1 (IC50 = 32 nM); reduces lung bacterial burden in a mouse model of chronic tuberculosis infection at 300 mg/kg and exhibits a synergistic effect when administered in combination with TMC207

Formal name: 1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

Synonyms: 

Molecular weight: 368.4

CAS: 1615713-87-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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