An inhibitor of mitochondrial F1FO-ATPase; slows ATP consumption following inhibition of cellular respiration; protects against ischemic cell death of HL-1 cells and rescues defective hemoglobin synthesis in pinotage (pnt) mutant zebrafish; increases A549 apoptosis in combination with ionizing radiation

BTB06584 – 5 mg

Brand:
Cayman
CAS:
219793-45-0
Storage:
-20
UN-No:
Non-Hazardous - /

BTB06584 (BTB) is an inhibitor of mitochondrial F1FO-ATP synthase (F1FO-ATPase) that has no effect on mitochondrial membrane potential (ΔΨm) or oxygen consumption.{38098} It slows ATP consumption following inhibition of cellular respiration. BTB (100 μM) protects against ischemic cell death of HL-1 cells and rescues defective hemoglobin synthesis in pinotage (pnt) mutant zebrafish. BTB, in combination with ionizing radiation, increases apoptosis of A549 cells.{38097}  

 

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Description

An inhibitor of mitochondrial F1FO-ATPase; slows ATP consumption following inhibition of cellular respiration; protects against ischemic cell death of HL-1 cells and rescues defective hemoglobin synthesis in pinotage (pnt) mutant zebrafish; increases A549 apoptosis in combination with ionizing radiation

Formal name: 4-chloro-benzoic acid, 2-nitro-5-(phenylsulfonyl)phenyl ester

Synonyms:  BTB

Molecular weight: 417.8

CAS: 219793-45-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Behavioral Neuroscience

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