A natural insulin mimic that activates IRTK (EC50 = 6 µM); induces glucose uptake in adipocytes and skeletal muscle without activating proliferation

Demethylasterriquinone B1 – 1 mg

Brand:
Cayman
CAS:
78860-34-1
Storage:
-20
UN-No:
Non-Hazardous - /

Demethylasterriquinone B1 (DMAQ B1) is a natural insulin mimic that activates insulin receptor tyrosine kinase (IRTK; EC50 = 6 µM).{33106,33107,33108,33109} It less potently activates IGF1R and EGFR (EC50s = 100 µM for both). DMAQ B1 induces glucose uptake in adipocytes and skeletal muscle cells without activating proliferation. DMAQ B1 binds GAPDH in vitro.{33105}  

 

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Description

A natural insulin mimic that activates IRTK (EC50 = 6 µM); induces glucose uptake in adipocytes and skeletal muscle without activating proliferation

Formal name: 2-[2-(1,1-dimethyl-2-propen-1-yl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-buten-1-yl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione

Synonyms:  DMAQ B1|L-783,281

Molecular weight: 506.6

CAS: 78860-34-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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