An inhibitor of PDE5 (IC50 = 19 nM); selective for PDE5 over PDE1

MBCQ – 1 mg

Brand:
Cayman
CAS:
150450-53-6
Storage:
-20
UN-No:
Non-Hazardous - /

MBCQ is an inhibitor of phosphodiesterase 5 (PDE5; IC50 = 19 nM).{48142} It is selective for PDE5 over PDE1, PDE2, PDE3, and PDE4 (IC50s = >100 µM for all). It induces relaxation of isolated porcine coronary arteries precontracted with prostaglandin F2α (PGF2α; EC50 = 190 nM).  

 

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Description

An inhibitor of PDE5 (IC50 = 19 nM); selective for PDE5 over PDE1, PDE2, PDE3, and PDE4 (IC50s = >100 µM for all); induces relaxation of isolated porcine coronary arteries precontracted with PGF2α (EC50 = 190 nM)

Formal name: N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine

Synonyms: 

Molecular weight: 313.7

CAS: 150450-53-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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