Induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~ 30 µM)

Ubiquitin Isopeptidase Inhibitor I – 10 mg

Brand:
Cayman
CAS:
108477-18-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 µM).{27605} It has also been shown to induce necrosis in apoptosis-resistant DKO cells.{32895}  

 

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Description

Induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~ 30 µM)

Formal name: tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide

Synonyms:  NSC 144303

Molecular weight: 414.4

CAS: 108477-18-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Necrosis||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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