A β2-AR agonist (Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor); selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM

Salbutamol – 250 mg

Brand:
Cayman
CAS:
18559-94-9
Storage:
-20
UN-No:
Non-Hazardous - /

Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).  

 

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Description

A β2-AR agonist (Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor); selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 μM, respectively); reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs (25-50 μg/kg, i.v.); reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs (1-2.5 and 10-20 μg/kg, i.v., respectively); reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 μg)

Formal name: α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol

Synonyms:  (±)-Salbutamol|AH 3365|DL-Salbutamol

Molecular weight: 239.3

CAS: 18559-94-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema

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