A calcium channel inhibitor; binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells; reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia at 3 mg/kg; dietary administration reduces reduces systolic blood pressure in spontaneously hypertensive rats at 50 and 100 mg/kg

Nisoldipine – 1 g

Brand:
Cayman
CAS:
63675-72-9
Storage:
22
UN-No:
Non-Hazardous - /

Nisoldipine is a calcium channel inhibitor.{33001} It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.{59310,33001} Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).{33001} In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.{59311} Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.{33005} Formulations containing nisoldipine have been used in the treatment of hypertension.  

 

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Description

A calcium channel inhibitor; binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells; reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia at 3 mg/kg; dietary administration reduces reduces systolic blood pressure in spontaneously hypertensive rats at 50 and 100 mg/kg

Formal name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-(2-methylpropyl) ester

Synonyms:  (±)-BAY-K-5552|(±)-Nisoldipine

Molecular weight: 388.4

CAS: 63675-72-9

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cardiovascular System|Vasculature|Vasodilation

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