Danirixin – 10 mg

Brand:
Cayman
CAS:
954126-98-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Danirixin is a potent and selective nonpeptide antagonist of chemokine receptor 2 (CXCR2) that inhibits IL-8 binding to CXCR2 with an IC50 value of 12.5 nM.{38046} Levels of IL-8 are increased in sputum of patients with chronic obstructive pulmonary disease (COPD).{38047} Formulations containing danirixin demonstrate dose-dependent inhibition of IL-8 binding to CXCR2 with no relevant adverse events in clinical trials and a Phase I trial in Japan is ongoing to determine the dosing regimen for Phase IIa trials in patients with COPD.{38046}  

 

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SKU: 20980 - Category:

Description

A potent and selective CXCR2 antagonist (IC50 = 12.5 nM for IL-8 binding),


Formal name: N-[4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl]-N’-(3-fluoro-2-methylphenyl)-urea

Synonyms:  GSK1325756|GSK1325756B

Molecular weight: 441.9

CAS: 954126-98-8

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity