A metabolite of 5-FU; less effective than 5-FU in killing cancer cells in vitro (IC50s = 3.3 and 560 µM for 5-FU and 5-FUH2

5,6-dihydro-5-Fluorouracil – 5 mg

Brand:
Cayman
CAS:
696-06-0
Storage:
-20
UN-No:
Non-Hazardous - /

5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil (5-FU; Item No. 14416) via the enzyme dihydropyrimidine dehydrogenase (DPD).{34392} Formulations containing 5-FU are used for the treatment of cancer. However, in patients lacking full DPD activity, severe adverse events, including death, can occur. 5-FUH2 is less toxic than 5-FU but is not as effective (IC50s = 3.3 and 560 µM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells).{34391}  

 

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Description

A metabolite of 5-FU; less effective than 5-FU in killing cancer cells in vitro (IC50s = 3.3 and 560 µM for 5-FU and 5-FUH2, respectively in WiDr human colon cancer cells)

Formal name: 5-fluorodihydro-2,4(1H,3H)-pyrimidinedione

Synonyms:  5-DHFU|5-Fluoro-5,6-dihydrouracil|5-Fluorodihydropyrimidine-2,4-dione|5-Fluorodihydrouracil|5-FUH2

Molecular weight: 132.1

CAS: 696-06-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer

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