The major active metabolite of the L-type calcium channel blocker verapamil; inhibits mycobacterial efflux pumps and the expansion of M. tuberculosis-specific T cells

Norverapamil (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
67812-42-4
Storage:
-20
UN-No:
Non-Hazardous - /

Norverapamil is the N-demethylated metabolite of verapamil (Item No. 14288), an L-type calcium channel blocker and P-glycoprotein inhibitor. It is the major active metabolite of verapamil with approximately 20% efficacy of its parent with regard to vasodilatory activity.{32942} Norverapamil has been shown to inhibit mycobacterial efflux pumps and the expansion of M. tuberculosis-specific T cells.{32941}  

 

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Description

The major active metabolite of the L-type calcium channel blocker verapamil; inhibits mycobacterial efflux pumps and the expansion of M. tuberculosis-specific T cells

Formal name: α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-benzeneacetonitrile, monohydrochloride

Synonyms:  D 591

Molecular weight: 477

CAS: 67812-42-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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