An iron chelator with antiproliferative effects; inhibits in vitro proliferation of SK-N-MC neuroepithelioma

Dp44mT – 25 mg

Brand:
Cayman
CAS:
152095-12-0
Storage:
-20
UN-No:
Non-Hazardous - /

Dp44mT is an iron chelator with antiproliferative effects.{38957} It inhibits in vitro proliferation of SK-N-MC neuroepithelioma, SK-Mel-28 melanoma, and MCF-7 breast cancer cells (IC50s = 30, 60, and 60 nM, respectively) but not of normal MRC-5 fibroblasts (IC50 = >25 µM). Dp44mT increases mobilization of 59Fe from SK-N-MC cells and M109 mouse lung carcinoma cells when used at concentrations of 25 and 1 µM, respectively. It dose-dependently increases apoptosis in M109 cells in vitro. Dp44mT (2.5 µM) increases expression of the metastasis suppressor protein NDRG1 in the DU145 and PC3 human prostate cancer cell lines to a greater degree than normal prostate epithelial cells (PrECs), while also increasing expression of the tumor suppressor protein PTEN in both DU145 cells and normal PrECs.{38958} Dp44mT also enhances cytotoxicity in several multidrug resistant human cancer cell lines following transport to lysosomes by P-glycoprotein.{38959} Dp44mT (0.4 mg/kg) inhibits M109 tumor growth in mice, reducing tumor weight to 47% of control.{38957} It also reduces tumor size and weight in an oral squamous cell carcinoma mouse xenograft model when administered at a dose of 0.5 mg/kg.{38960}  

 

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Description

An iron chelator with antiproliferative effects; inhibits in vitro proliferation of SK-N-MC neuroepithelioma, SK-Mel-28 melanoma, and MCF-7 breast cancer cells (IC50s = 30, 60, and 60 nM, respectively); increases mobilization of 59Fe from SK-N-MC cells and M109 mouse lung carcinoma cells (25 and 1 µM, respectively); enhances cytotoxicity in several multidrug resistant human cancer cell lines following transport to lysosomes by P-glycoprotein; inhibits M109 tumor growth in mice, reducing tumor weight to 47% of control values (0.4 mg/kg); reduces tumor size and weight in an oral squamous cell carcinoma mouse xenograft model (0.5 mg/kg),

Formal name: 2-(di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide

Synonyms: 

Molecular weight: 285.4

CAS: 152095-12-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Cell Death|Ferroptosis

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