A bacterial metabolite; reduces MIF production by isolated human lymphocytes at 0.25 µg/ml; decreases spontaneous migration of WEHI-3 murine monocytes at 0.5 and 5 µg/ml; forms intra- and interstrand adducts with DNA in the presence of thiols; reduces tumor growth in P388 leukemia and B16 melanoma mouse models (MED = 0.05 mg/kg for both); toxic to mice (LD50 = 2 mg/kg)

Mitomycin A – 1 mg

Brand:
Cayman
CAS:
4055-39-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Mitomycin A is a bacterial metabolite originally isolated from S. caespitosus.{48336} It reduces migration inhibition factor (MIF) production by isolated human lymphocytes when used at a concentration of 0.25 µg/ml and decreases spontaneous migration of WEHI-3 murine monocytes when used at concentrations of 0.5 and 5 µg/ml.{48337} Mitomycin A forms intra- and interstrand adducts with DNA in the presence of thiols, such as dithiothreitol (DTT).{48338} It reduces tumor growth in P388 leukemia and B16 melanoma mouse models with a minimum effective dose (MED) of 0.05 mg/kg for both but is toxic to mice with an LD50 value of 2 mg/kg.{48339,48336}  

 

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Description

A bacterial metabolite; reduces MIF production by isolated human lymphocytes at 0.25 µg/ml; decreases spontaneous migration of WEHI-3 murine monocytes at 0.5 and 5 µg/ml; forms intra- and interstrand adducts with DNA in the presence of thiols; reduces tumor growth in P388 leukemia and B16 melanoma mouse models (MED = 0.05 mg/kg for both); toxic to mice (LD50 = 2 mg/kg)

Formal name: (1aS,8S,8aR,8bS)-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methyl-azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione

Synonyms:  NSC 75986

Molecular weight: 349.3

CAS: 4055-39-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|DNA Alkylating Agents||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|DNA Damage and Repair||Research Area|Toxicology|Cell Health & Viability

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