A potent agonist of GPR54 (OT7T175

Metastin (45-54) – 1 mg

Brand:
Cayman
CAS:
374675-21-5
Storage:
-20
UN-No:
Non-Hazardous - /

Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product.{32826} It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)).{32826} Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM).{32827} It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.{32825}  

 

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Description

A potent agonist of GPR54 (OT7T175, AXOR12); induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM); inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM

Formal name: L-tyrosyl-L-asparaginyl-L-tryptophyl-L-asparaginyl-L-seryl-L-phenylalanylglycyl-L-leucyl-L-arginyl-L-phenylalaninamide

Synonyms:  Kisspeptin 10 (human)

Molecular weight: 1,302.50

CAS: 374675-21-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Migration & Metastasis

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