A β2-adrenergic receptor antagonist with peripheral vasodilator activity; expanded hematopoietic cell population and protected zebrafish from ionizing radiation (5 µM); inhibited histone acetylation; long-term treatment (3 mg/day for 4 months) impaired hepatocyte histone acetylation and liver regeneration

Todralazine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
3778-76-5
Storage:
-20
UN-No:
Non-Hazardous - /

Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity.{33946,33945} Administration of todralazine (5 µM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation.{33945} It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration.{33947}  

 

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Description

A β2-adrenergic receptor antagonist with peripheral vasodilator activity; expanded hematopoietic cell population and protected zebrafish from ionizing radiation (5 µM); inhibited histone acetylation; long-term treatment (3 mg/day for 4 months) impaired hepatocyte histone acetylation and liver regeneration

Formal name: 2-(1-phthalazinyl)-hydrazinecarboxylic acid, ethyl ester, monohydrochloride

Synonyms:  Apirachol|Binazine|Ecarazine

Molecular weight: 268.7

CAS: 3778-76-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Acetylation

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