A broad-spectrum carboxypenicillin antibiotic; active against Gram-negative and certain Gram-positive bacteria

Carbenicillin (sodium salt) – 10 g

Brand:
Cayman
CAS:
4800-94-6
Storage:
-20
UN-No:
Non-Hazardous - /

Carbenicillin is a broad-spectrum carboxypenicillin antibiotic.{42909} It is active against Gram-negative and certain Gram-positive bacteria, including S. pyogenes, S. epidermidis, P. mirabilis, P. vulgaris, E. coli, and P. aeruginosa (MICs = 0.19, 1.56, 1.56, 3.12, 3.12, and 50 μg/ml, respectively). It is also active against penicillinase-producing and non-producing strains of S. aureus (MICs = 1.56 and 12.5 μg/ml, respectively). Carbenicillin is protective against systemic S. pyogenes, P. vulgaris, E. coli, and S. aureus infection in a mouse model of systemic lethal infection with 50% protective dose (PD50) values of 7.8, 224, 19.3, and 34 mg/kg, respectively. It also decreases viable colony counts in the kidney in a rat model of P. vulgaris or E. coli urinary tract infection when administered at a dose of 100 mg/kg. Formulations containing carbenicillin have previously been used in the treatment of upper and lower urinary tract infections and prostatitis.  

 

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Description

A broad-spectrum carboxypenicillin antibiotic; active against Gram-negative and certain Gram-positive bacteria, including S. pyogenes, S. epidermidis, P. mirabilis, P. vulgaris, E. coli, and P. aeruginosa (MICs = 0.19, 1.56, 1.56, 3.12, 3.12, and 50 μg/ml, respectively); inhibits the growth of penicillinase-producing and non-producing strains of S. aureus (MICs = 1.56 and 12.5 μg/ml, respectively); protective against systemic S. pyogenes, P. vulgaris, E. coli, and S. aureus infection in a mouse model of systemic lethal infection (PD50s = 7.8, 224, 19.3, and 34 mg/kg, respectively); decreases viable colony counts in the kidney in a rat model of P. vulgaris or E. coli urinary tract infection at 100 mg/kg

Formal name: (2S,5R,6R)-6-[(2-carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, disodium salt

Synonyms:  BRL 2064|CP 15,639-2|NSC 111071|α-Carboxybenzylpenicillin

Molecular weight: 422.4

CAS: 4800-94-6

Purity: ≥80%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Penicillins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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