An inhibitor of actin assembly and cytokinesis; blocks cleavage furrow formation in synchronous HeLa cells; induces tetraploidy and arrests the cell cycle indefinitely in the G1 phase in REF-52 cells; increases the drug sensitivity of multidrug resistant SKVLB1 cells to paclitaxel and doxorubicin in vitro

Dihydrocytochalasin B – 500 µg

Brand:
Cayman
CAS:
39156-67-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Dihydrocytochalasin B (DCB) is a member of the cytochalasin mycotoxin family that inhibits actin assembly.{38141} It blocks cleavage furrow formation and cytokinesis in synchronous HeLa cells at a concentration of 10 μM. DCB induces tetraploidy and arrests the cell cycle indefinitely in the G1 phase in REF-52 cells.{38143} It also increases the drug sensitivity of multidrug resistant SKVLB1 cells to paclitaxel (Item No. 10461) and doxorubicin (Item No. 15007) in vitro.{38142}  

 

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Description

An inhibitor of actin assembly and cytokinesis; blocks cleavage furrow formation in synchronous HeLa cells; induces tetraploidy and arrests the cell cycle indefinitely in the G1 phase in REF-52 cells; increases the drug sensitivity of multidrug resistant SKVLB1 cells to paclitaxel and doxorubicin in vitro ,

Formal name: (5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-4,5,6,7,8,9,10,12a,13,14,15,15a,16,17-tetradecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(3H)-dione

Synonyms:  DCB

Molecular weight: 481.6

CAS: 39156-67-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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