A selective eEF-2K inhibitor (IC50 = 440 nM); disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM

TX-1918 – 1 mg

Brand:
Cayman
CAS:
503473-32-3
Storage:
-20
UN-No:
Non-Hazardous - /

TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM).{33394} It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively).{33394} TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 (Item No. 10010248).{33394}  

 

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Description

A selective eEF-2K inhibitor (IC50 = 440 nM); disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with low mitochondrial toxicity

Formal name: 2-[(4-hydroxy-3,5-dimethylphenyl)methylene]-4-cyclopentene-1,3-dione

Synonyms: 

Molecular weight: 228.2

CAS: 503473-32-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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