A limonoid triterpenoid; reduces HIV-1 replication in infected PBMCs (EC50 = 52.2 μM); dose-dependently reduces HUVEC proliferation

Nomilin – 10 mg

Brand:
Cayman
CAS:
1063-77-0
Storage:
-20
UN-No:
Non-Hazardous - /

Nomilin is a limonoid triterpenoid that has been found in grapefruit seeds and has diverse biological activities, including antiviral, antiproliferative, and anti-obesity properties.{42298} It dose-dependently reduces HIV-1 replication in infected human peripheral blood mononuclear cells (PBMCs; EC50 = 52.2 μM) and reduces human umbilical vein endothelial cell (HUVEC) proliferation, invasion, tube formation, and matrix metalloproteinase-2 (MMP-2) and MMP-9 activity without reducing cell viability when used at concentrations ranging from 5 to 25 µg/ml.{42299,42300} Nomilin (100 μM) increases luciferase activity 5.5-fold when the G protein-coupled receptor TGR5 is expressed in HEK293 cells with a TGR5-dependent reporter gene.{42301} It increases GST activity in the small intestinal mucosa, liver, and forestomach of mice by 4.17-, 3.44-, and 1.16-fold, respectively, when administered at a dose of 10 mg/kg.{42298} Nomilin (0.2% w/w, p.o.) completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet.{42301} It also increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells when administered at a dose of 10 μmol/kg.{42302}  

 

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Description

A limonoid triterpenoid; reduces HIV-1 replication in infected PBMCs (EC50 = 52.2 μM); dose-dependently reduces HUVEC proliferation, invasion, tube formation, and MMP-2 and MMP-9 activity at 5-25 μg/ml; increases GST activity in small intestinal mucosa, liver, and forestomach homogenates of mice by 4.17-, 3.44-, and 1.16-fold, respectively, at 10 mg; increases TGR5-dependent luciferase activity 5.5-fold in HEK293 cells at 100 μM; completely prevents weight gain and reduces serum glucose and insulin levels by 30 and 89.8%, respectively, in mice fed a high-fat diet at 0.2%; increases the white blood cell count and the specific antibody titer in blood by approximately 10-fold in mice in response to sheep red blood cells at 10 μmol/kg ,

Formal name: (1S,3aS,4aR,4bR,6aR,11S,11aR,11bR,13aS)-11-(acetyloxy)-1-(3-furanyl)decahydro-4b,7,7,11a,13a-pentamethyl-oxireno[4,4a]-2-benzopyrano[6,5-g][2]benzoxepin-3,5,9(3aH,4bH,6H)-trione

Synonyms:  NSC 297134

Molecular weight: 514.6

CAS: 1063-77-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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