An internal standard for the quantification of lithocholic acid by GC- or LC-MS

Lithocholic Acid-d4 – 500 µg

Brand:
Cayman
CAS:
83701-16-0
Storage:
-20
UN-No:
Non-Hazardous - /

Lithocholic acid-d4 is intended for use as an internal standard for the quantification of lithocholic acid (Item No. 20253) by GC- or LC-MS. Lithocholic acid is a secondary bile acid that has been shown to cause cholestasis in animal models and has also been implicated in carcinogenesis.{32395,10150} It is produced from chenodeoxycholic acid by bacterial action in the colon and can be conjugated with glycine or taurine. Whereas in normal colonic epithelium lithocholic acid promotes apoptosis, it has been shown to suppress apoptosis in pre-malignant colonic epithelium in the presence of a carcinogen.{32394} Lithocholic acid can activate the pregnane X receptor and the vitamin D receptor, which may serve as a biological sensor to regulate lithocholic acid-induced toxicity.{32396,10150,16793}  

 

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Description

An internal standard for the quantification of lithocholic acid by GC- or LC-MS,

Formal name: (5β)-3ɑ-hydroxy-cholan-24-oic-2,2,4,4-d4 acid

Synonyms:  Lithocholate-d4

Molecular weight: 380.6

CAS: 83701-16-0

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor

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