Description
A coumarin derivative with diverse biological activities; inhibits EGFR, PKA, and PKC in vitro (IC50s = 7.67, 9.33, and 25.01 µM, respectively); inhibits cell proliferation (IC50 = 73 µM) in MCF-7 breast carcinoma cells; decreases the generation of ROS and production of MDA and increases SOD activity and the GSH:GSSG ratio in RAW 264.7 cells; prevents t-BHP-induced cytotoxicity and ROS overproduction in wild-type, but not Nrf2-/-, RAW 264.7 cells and increases the expression of proteins downstream of Nrf2
Formal name: 7,8-dihydroxy-2H-1-benzopyran-2-one
Synonyms: 7,8-Dihydroxycoumarin|NSC 633563
Molecular weight: 178.1
CAS: 486-35-1
Purity: ≥90%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|cAMP Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
