A first generation tricyclic antidepressant that is extensively metabolized to desipramine; potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM

Lofepramine – 10 mg

Brand:
Cayman
CAS:
23047-25-8
Storage:
-20
UN-No:
Non-Hazardous - /

Lofepramine is a first generation tricyclic antidepressant that is extensively metabolized to desipramine.{32550} It potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM, respectively) and less potently antagonizes serotonin, histamine, and muscarinic receptors.{22877,25803,25806}  

 

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Description

A first generation tricyclic antidepressant that is extensively metabolized to desipramine; potently inhibits serotonin and norepinephrine transporters (Kds = 70 and 5.4 nM, respectively)

Formal name: 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]-ethanone

Synonyms:  Lopramine

Molecular weight: 419

CAS: 23047-25-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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