A cyclic peptide hormone; SST receptor agonist (IC50s = 0.22

Somatostatin-14 (acetate) – 5 mg

Brand:
Cayman
CAS:
54472-66-1
Storage:
-20
UN-No:
Non-Hazardous - /

Somatostatin-14 is a natural cyclic peptide hormone derived from the preprohormone, somatostatin.{33263} It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5 (IC50s = 0.22, 0.10, 0.28, 1.23, and 0.30 nM, respectively, in CCL39 cells expressing human recombinant receptors).{42022} It inhibits cAMP accumulation induced by forskolin (Item No. 11018) in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5 (EC50s = 6.16, 4.37, 17.38, 2.95, and 4.67 nM, respectively).{42023} Somatostatin-14 inhibits the release of growth hormone, prolactin, thyrotropin, glucagon, and insulin, as well as other signaling molecules.{33263,5903,12953}  

 

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SKU: 20809 - Category:

Description

A cyclic peptide hormone; SST receptor agonist (IC50s = 0.22, 0.10, 0.28, 1.23, and 0.30 nM, respectively, in CCL39 cells expressing human recombinant SST1-5); inhibits forskolin-induced cAMP accumulation in CCL39 cells expressing human recombinant SST1-5 (EC50s = 6.16, 4.37, 17.38, 2.95, and 4.67 nM, respectively); inhibits the release of growth hormone, prolactin, thyrotropin, glucagon, and insulin, as well as other signaling molecules

Formal name: somatostatin, monoacetate

Synonyms: 

Molecular weight: 1,697.90

CAS: 54472-66-1

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Neuroendocrinology

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