A selective DP2 receptor antagonist with a pIC50 value of 8.4; blocks functional responses in eosinophils

AZD 1981 – 25 mg

Brand:
Cayman
CAS:
802904-66-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

AZD 1981 is a prostaglandin D2 (PGD2; Item No. 12010) receptor antagonist with a pIC50 value of 8.4 for CRTH2/DP2 and >1,000-fold selectivity over DP1.{32940} It has been shown to block functional responses in eosinophils, Th2 cells, and basophils and is currently under clinical evaluation as a potential therapeutic agent in respiratory diseases including asthma.{32940,32112}  

 

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Description

A selective DP2 receptor antagonist with a pIC50 value of 8.4; blocks functional responses in eosinophils, Th2 cells, and basophils

Formal name: 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid

Synonyms: 

Molecular weight: 388.9

CAS: 802904-66-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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