A dopamine D2 receptor antagonist; binds to rat recombinant D2 receptors (Ki = 4.7 nM); binds to D2 in rat striatal membranes (Ki = 2.9 nM); binds to rat recombinant D3 receptors (Ki = 35 nM); binds to the 5-HT3 receptor in N1E-115 mouse neuroblastoma cell membranes (Ki = 1.2 μM); increases the latency to paw licking in a hot plate test at 2 mg/kg

Prochlorperazine (maleate) – 500 mg

Brand:
Cayman
CAS:
84-02-6
Storage:
-20
UN-No:
Non-Hazardous - /

Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.{30683,39858} It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM).{30683,39857} Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor.{39859} It also inhibits emesis induced by apomorphine (Item No. 16094) in dogs (ED50 = 0.34 mg/kg).{39860} Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.  

 

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Description

A dopamine D2 receptor antagonist; binds to rat recombinant D2 receptors (Ki = 4.7 nM); binds to D2 in rat striatal membranes (Ki = 2.9 nM); binds to rat recombinant D3 receptors (Ki = 35 nM); binds to the 5-HT3 receptor in N1E-115 mouse neuroblastoma cell membranes (Ki = 1.2 μM); increases the latency to paw licking in a hot plate test at 2 mg/kg, indicating analgesia; inhibits apomorphine-induced emesis in dogs (ED50 = 0.34 mg/kg),

Formal name: 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine, dimaleate

Synonyms: 

Molecular weight: 606.1

CAS: 84-02-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Pain Research

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