Description
An antagonist of CRF1 (Ki = 2.7 nM); selective for CRF1 over CRF2 (Ki = >10 μM); inhibits CRF-induced increases in ACTH levels in rat plasma (ID50 = 10 mg/kg); increases the time spent in the open arms of the elevated plus maze in rats at 1 mg/kg; decreases immobility time in the forced swim test in a rat model of depressive-like behavior at 10 mg/kg, twice per day for 14 days; decreases stress-induced reinstatement of cocaine or heroin self-administration in cocaine- and heroin-trained rats, respectively, at 15 and 30 mg/kg,
Formal name: N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, monohydrochloride
Synonyms:
Molecular weight: 401
CAS: 257639-98-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Neuroendocrinology
