A metal chelating compound that potently and reversibly inhibits NF-κB activation (100 µM); prevents TNF-α gene expression and protein production (300 µM); arrests the cell cycle at G1; has antioxidant properties

Pyrrolidinedithiocarbamic Acid (ammonium salt) – 10 g

Brand:
Cayman
CAS:
5108-96-3
Storage:
-20
UN-No:
Non-Hazardous - /

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 µM).{33926} At 300 µM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application.{33928} In vascular smooth muscle cells, PDTC (10 µM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway.{33925} PDTC (100 µM) also has antioxidant properties.{33927}  

 

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Description

A metal chelating compound that potently and reversibly inhibits NF-κB activation (100 µM); prevents TNF-α gene expression and protein production (300 µM); arrests the cell cycle at G1; has antioxidant properties

Formal name: 1-pyrrolidinecarbodithioic acid, monoammonium salt

Synonyms:  PDTC|Pyrrolidinedithiocarbamate

Molecular weight: 164.3

CAS: 5108-96-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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