An inhibitor of FGFRs (IC50s = 13

FIIN-3 – 5 mg

Brand:
Cayman
CAS:
1637735-84-2
Storage:
-20
UN-No:
Non-Hazardous - /

FIIN-3 is an inhibitor of FGF receptors (FGFRs; IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively).{32873} It is selective for FGFRs over a panel of 456 kinases at a concentration of 1 μM, however, it does inhibit EGFR (IC50 = 204 nM). FIIN-3 inhibits growth of Ba/F3 cells that are dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = TEL/V564M-dependent Ba/F3 cells. FIIN-3 also inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM).  

 

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SKU: 20709 - Category:

Description

An inhibitor of FGFRs (IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively); selective for FGFRs over a panel of 456 kinases (1 μM); inhibits EGFR (IC50 =204 nM); inhibits growth of Ba/F3 cells dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = TEL/V564M-dependent Ba/F3 cells; inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM)

Formal name: N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-2-propenamide

Synonyms: 

Molecular weight: 691.6

CAS: 1637735-84-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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