A sulfated glycosaminoglycan mimetic that inhibits Aβ aggreagation

Tramiprosate – 5 g

Brand:
Cayman
CAS:
3687-18-1
Storage:
22
UN-No:
Non-Hazardous - /

Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation.{32513} Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates.{32515} It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.{32514}  

 

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Description

A sulfated glycosaminoglycan mimetic that inhibits Aβ aggreagation, yet promotes tau polymerization; analog of GABA that can act as a partial agonist of GABAA receptors and an antagonist at GABAB receptors

Formal name: 3-amino-1-propanesulfonic acid

Synonyms:  3-Sulfopropylamine|Homotaurine|NC 531|NC 758|NSC 77071

Molecular weight: 139.2

CAS: 3687-18-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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