A photosensitizer; accumulates in tumor cells and when stimulated with light at 655 nm in the presence of oxygen

HPPH – 5 mg

Brand:
Cayman
CAS:
149402-51-7
Storage:
-20
UN-No:
Non-Hazardous - /

HPPH is a chlorin that acts as a photosensitizer in photodynamic therapy (PDT) when stimulated with light at 655 nm.{39227} When administered systemically, HPPH accumulates in tumor cells and, when stimulated with light in the presence of oxygen, reactive oxygen species (ROS) are generated, leading to necrosis within the tumor. HPPH, at a dose of 0.5 mg/kg, increases survival in a nude rat model of glioma.{39228} It works synergistically with gemcitabine (Item No. 11690) in several pancreatic cancer cell lines to induce cell death.{39229}  

 

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Description

A photosensitizer; accumulates in tumor cells and when stimulated with light at 655 nm in the presence of oxygen, ROS are generated, leading to tumor necrosis; increases survival in a nude rat model of glioma when administered at a dose of 0.5 mg/kg; induces cell death synergistically with gemcitabine in pancreatic cancer cell lines,

Formal name: (3S,4S)-14-ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid

Synonyms:  Photochlor

Molecular weight: 636.8

CAS: 149402-51-7

Purity: ≥98% (mixture of epimers)

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Cell Death|Necrosis||Research Area|Cancer|Tumor Microenvironment

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