An antibiotic that is cytotoxic to human colon cancer SW620 cells (IC50 = 14.4 μM)

21-hydroxy Oligomycin A – 5 mg

Brand:
Cayman
CAS:
102042-09-1
Storage:
-20
UN-No:
Non-Hazardous - /

21-hydroxy Oligomycin A is an antibiotic that was first isolated from S. cyaneogriseus ssp. noncyanogenus (LL-F28249). It is reported to be cytotoxic to human colon cancer SW620 cells (IC50 = 14.4 μM), to inhibit the ABC transporter efflux pump P-glycoprotein, and to prevent K-Ras plasma membrane localization (IC50 = 4.82 nM).{31741}  

 

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Description

An antibiotic that is cytotoxic to human colon cancer SW620 cells (IC50 = 14.4 μM), inhibits the ABC transporter efflux pump P-glycoprotein, and prevents K-Ras plasma membrane localization (IC50 = 4.82 nM)

Formal name: (1R,2’S,4E,5’S,6S,6’S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-ethyl-3′,4′,5′,6′-tetrahydro-7,11,14,15,23-pentahydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2′-[2H]pyran]-3,9,13-trione

Synonyms: 

Molecular weight: 807.1

CAS: 102042-09-1

Purity: ≥95%

Formulation: A lyophilisate

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|GTPases||Research Area|Cancer|Multidrug Resistance

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