An analog of leptomycin B that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml) as well as to Lewis lung carcinoma in mice

Anguinomycin A – 100 µg

Brand:
Cayman
CAS:
111278-01-4
Storage:
-20
UN-No:
Non-Hazardous - /

Anguinomycin A is an antibiotic first isolated from a Streptomyces sp. and analog of leptomycin B (Item No. 10004976) that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml).{32130} It also demonstrates antitumor activity at 62.5 µg/kg/day against Lewis lung carcinoma in mice.{32130}  

 

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SKU: 20598 - Category:

Description

An analog of leptomycin B that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml) as well as to Lewis lung carcinoma in mice

Formal name: 19-(3,6-dihydro-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Synonyms:  5-Demethylleptomycin A

Molecular weight: 512.7

CAS: 111278-01-4

Purity: ≥95%

Formulation: A film

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death

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