A μ-opioid receptor agonist (Ki = 1.1 nM); selective for μ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM

PZM21 – 10 mg

Brand:
Cayman
CAS:
1997387-43-5
Storage:
-20
UN-No:
- /

PZM21 is a μ-opioid receptor agonist (Ki = 1.1 nM).{32410} It is selective for μ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM, respectively). PZM21 induces Gi/o signaling (EC50 = 4.6 nM in HEK293T cells expressing human receptors) but has no detectable activity in a β-arrestin2 recruitment assay. In vivo, PZM21 (10, 20, and 40 mg/kg) induces analgesia in the hot plate test and reduces formalin-induced paw licking in mice when administered at a dose of 40 mg/kg.  

 

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Description

A μ-opioid receptor agonist (Ki = 1.1 nM); selective for μ- over κ- and δ-opioid receptors (Kis = 18 and 506 nM, respectively); induces Gi/o signaling (EC50 = 4.6 nM in HEK293T cells expressing human receptors) but has no detectable activity in a β-arrestin2 recruitment assay; induces analgesia in the hot plate test at 10, 20, and 40 mg/kg and reduces formalin-induced paw licking in mice at 40 mg/kg

Formal name: N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N’-[(1S)-1-methyl-2-(3-thienyl)ethyl]-urea

Synonyms: 

Molecular weight: 361.5

CAS: 1997387-43-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Pain Research

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