A neuronal nAChR agonist; particularly effective at α6 and α7 subunit-containing neuronal nAChRs (EC50s = 4 and 17 µM

(±)-Nornicotine – 500 mg

Brand:
Cayman
CAS:
5746-86-1
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Nornicotine is a metabolite of nicotine (Item No. 16535) that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 µM, respectively, when expressed in Xenopus oocytes.{34465} Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line.{34463} It is generally thought to be free from abuse potential, but it has been self-administered by rats.{34462,34464} It can be detected in urine.{34466}  

 

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Description

A neuronal nAChR agonist; particularly effective at α6 and α7 subunit-containing neuronal nAChRs (EC50s = 4 and 17 µM, respectively); promotes cell migration and destabilizes cell-cell junctions

Formal name: 3-(2-pyrrolidinyl)-pyridine

Synonyms:  (R,S)-Nornicotine|DL-Nornicotine

Molecular weight: 148.2

CAS: 5746-86-1

Purity: ≥95%

Formulation: A neat oil

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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