An intermediate in the synthesis of ubiquinones that has anticancer activity; inhibits the growth of SKOV-3

2,3-Dimethoxy-5-methyl-p-benzoquinone – 5 g

Brand:
Cayman
CAS:
605-94-7
Storage:
-20
UN-No:
Non-Hazardous - /

2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E.{43190,43191} It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells.{43192} It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.  

 

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Description

An intermediate in the synthesis of ubiquinones that has anticancer activity; inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively); halts the cell cycle at the G2/M phase, increases ROS production, and induces autophagy and apoptosis in SKOV-3 human ovarian carcinoma cells; downregulates the protooncogene HER-2 in vitro; decreases the incidence of tumors and tumor burden in a SKOV-3 mouse xenograft model at 2.5 mg/kg every four days

Formal name: 2,3-dimethoxy-5-methyl-2,5-cyclohexadiene-1,4-dione

Synonyms:  Coenzyme Q0|CoQ0

Molecular weight: 182.2

CAS: 605-94-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Tumor Microenvironment

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