An AMPA receptor antagonist; inhibits AMPA receptor-mediated calcium uptake in rat cerebellar neurons (IC50 = 74 nM); inhibits pentylenetetrazol- and AMPA-induced seizures in mice (ID50s = 3.8 and 3.6 mg/kg

CP-392,110 (maleate) – 10 mg

Brand:
Cayman
CAS:
199656-46-7
Storage:
-20
UN-No:
Non-Hazardous - /

CP-392,110 is an AMPA receptor antagonist.{53055} It inhibits AMPA receptor-mediated calcium uptake in rat cerebellar neurons (IC50 = 74 nM). CP-392,110 inhibits seizures induced by pentylenetetrazol (Item No. 18682) or AMPA (Item No. 14571) in mice with ID50 values of 3.8 and 3.6 mg/kg, respectively.  

 

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Description

An AMPA receptor antagonist; inhibits AMPA receptor-mediated calcium uptake in rat cerebellar neurons (IC50 = 74 nM); inhibits pentylenetetrazol- and AMPA-induced seizures in mice (ID50s = 3.8 and 3.6 mg/kg, respectively)

Formal name: 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone, (2Z)-2-butenedioate

Synonyms: 

Molecular weight: 579

CAS: 199656-46-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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