A GPX4 inhibitor selectively lethal to oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts

ML-162 – 1 mg

Brand:
Cayman
CAS:
1035072-16-2
Storage:
-20
UN-No:
Non-Hazardous - /

ML-162 is a GPX4 inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).{30722,33150} It shares a similar structure but is more potent and selective than (1S,3R)-RSL3 (Item No. 19288), a previously reported inhibitor of RAS oncogene-expressing cells.{33150}  

 

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SKU: 20455 - Category:

Description

A GPX4 inhibitor selectively lethal to oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively),

Formal name: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide

Synonyms: 

Molecular weight: 477.4

CAS: 1035072-16-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Death|Ferroptosis

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