A calcium channel blocker that selectively antagonizes cardiovascular calcium channels; demonstrates antihypertensive activity by reducing peripheral vascular resistance; decreases blood pressure in spontaneously hypertensive rats

Barnidipine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
104757-53-1
Storage:
-20
UN-No:
Non-Hazardous - /

Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.{34407} It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.{34406} Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure.{34405}  

 

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Description

A calcium channel blocker that selectively antagonizes cardiovascular calcium channels; demonstrates antihypertensive activity by reducing peripheral vascular resistance; decreases blood pressure in spontaneously hypertensive rats

Formal name: (4S)-3,5-pyridinedicarboxylic acid, 3-methyl 5-[(3S)-1-(phenylmethyl)-3-pyrrolidinyl] ester, monohydrochloride

Synonyms:  YM-09730-5

Molecular weight: 528

CAS: 104757-53-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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