An inhibitor of class I PI3K isoforms (IC50s = 0.5

Copanlisib – 5 mg

Brand:
Cayman
CAS:
1032568-63-0
Storage:
-20
UN-No:
Non-Hazardous - /

Copanlisib is an inhibitor of class I phosphoinositide 3-kinase (PI3K) isoforms (IC50s = 0.5, 3.7, 6.4, and 0.7 nM for α, β, γ, and δ, respectively).{32958} It is weakly active or inactive against numerous other kinases. Copanlisib is effective in vivo when administered intravenously, inhibiting PI3K signaling and inducing tumor regression via apoptosis in xenograft tumors in mice.{32958,32959}  

 

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Description

An inhibitor of class I PI3K isoforms (IC50s = 0.5, 3.7, 6.4, and 0.7 nM for α, β, γ, and δ, respectively); inhibits PI3K signaling and induces tumor regression via apoptosis in xenograft tumors in mice

Formal name: 2-amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-5-pyrimidinecarboxamide

Synonyms:  BAY 80-6946

Molecular weight: 480.5

CAS: 1032568-63-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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