A Chk1 inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents; used in xenograft tumor models to potentiate the antitumor efficacy of various chemotherapeutic agents

LY2603618 – 10 mg

Brand:
Cayman
CAS:
911222-45-2
Storage:
-20
UN-No:
Non-Hazardous - /

LY2603618 is a checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents.{32250} It can inhibit Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation.{32251} LY2603618 has been used in xenograft tumor models to potentiate the antitumor efficacy of chemotherapeutic agents such as gemcitabine (Item No. 11690).{32249}  

 

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Description

A Chk1 inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents; used in xenograft tumor models to potentiate the antitumor efficacy of various chemotherapeutic agents

Formal name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N’-(5-methyl-2-pyrazinyl)-urea

Synonyms:  IC-83|Rabusertib

Molecular weight: 436.3

CAS: 911222-45-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Checkpoint Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cancer|DNA Damage and Repair

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