A potent inhibitor of MMP-2 and MMP-9 (IC50s = 310 and 240 nM

MMP-2/MMP-9 Inhibitor I – 5 mg

Brand:
Cayman
CAS:
193807-58-8
Storage:
-20
UN-No:
Non-Hazardous - /

MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 (IC50s = 310 and 240 nM, respectively).{32343} It acts by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I is active in vivo as well as in vitro and blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models.{32343} This compound has been used to elucidate the roles of MMP-2 and MMP-9 in diverse systems, including mammary epithelial cell transformation, neuronal dysfunction, lymphocyte recruitment, and progressive hereditary kidney disease.{32340,32341,32342,32344}  

 

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Description

A potent inhibitor of MMP-2 and MMP-9 (IC50s = 310 and 240 nM, respectively) that is active in vivo as well as in vitro

Formal name: N-([1,1′-biphenyl]-4-ylsulfonyl)-D-phenylalanine

Synonyms:  Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor I

Molecular weight: 381.4

CAS: 193807-58-8

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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