LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541

Leukotriene D4 – 100 µg

Brand:
Cayman
CAS:
73836-78-9
Storage:
-80
UN-No:
De Minimis - 1170 / 3

LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl-leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}  

 

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Description

LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first CysLT metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}

Formal name: 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid

Synonyms:  LTD4

Molecular weight: 496.7

CAS: 73836-78-9

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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