A selective histamine H1-receptor antagonist with anti-allergic effects that is a prodrug to fexofenadine; cardiotoxic

Terfenadine – 1 g

Brand:
Cayman
CAS:
50679-08-8
Storage:
-20
UN-No:
Non-Hazardous - /

Terfenadine is a selective histamine H1-receptor antagonist with anti-allergic effects that lacks central nervous system depressant activity.{32989} It is a prodrug that undergoes extensive first-pass hepatic metabolism by the cytochrome P450 enzyme CYP3A4 to its pharmacologically active metabolite fexofenadine (Item No. 18191).{32988} Terfenadine is reported to be cardiotoxic, inducing QT interval prolongation by blocking cardiac potassium channels.{32990}  

 

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Description

A selective histamine H1-receptor antagonist with anti-allergic effects that is a prodrug to fexofenadine; cardiotoxic, inducing QT interval prolongation by blocking cardiac potassium channels

Formal name: α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

Synonyms:  (±)-Terfenadine|DL-Terfenadine|MDL 9918|NSC 665802

Molecular weight: 471.7

CAS: 50679-08-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy

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