A selective p38α MAPK inhibitor (IC50 = 26 nM in a cell-free assay); demonstrates anti-inflammatory activity in chronic disease models

PH-797804 – 1 mg

Brand:
Cayman
CAS:
586379-66-0
Storage:
-20
UN-No:
Non-Hazardous - /

PH-797804 is an inhibitor of p38α MAPK with an IC50 value of 26 nM in a cell-free assay.{31975,21533} It is 4-fold more selective for p38α compared to p38β and does not inhibit JNK2 or ERK at concentrations up to 1 µM.{31975} PH-797804 treatment for 10 days in vivo demonstrates anti-inflammatory activity in chronic inflammatory disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and collagen-induced arthritis in mice.{31975}  

 

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SKU: 20244 - Category:

Description

A selective p38α MAPK inhibitor (IC50 = 26 nM in a cell-free assay); demonstrates anti-inflammatory activity in chronic disease models

Formal name: 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethyl-benzamide

Synonyms: 

Molecular weight: 477.3

CAS: 586379-66-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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