A PKC inhibitor (IC50 = 62 nM) that is cytotoxic to the growth of HeLa S3 cells

UCN-02 – 1 mg

Brand:
Cayman
CAS:
121569-61-7
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

UCN-02 is a derivative of staurosporine (Item No. 81590) and a stereoisomer of UCN-01 (Item No. 18130) first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite.{31858} UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.{31858}  

 

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SKU: 20221 - Category:

Description

A PKC inhibitor (IC50 = 62 nM) that is cytotoxic to the growth of HeLa S3 cells

Formal name: (3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Synonyms:  7-epi-hydroxy Staurosporine

Molecular weight: 482.5

CAS: 121569-61-7

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|PKC Signaling

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