A natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170

L-Quisqualic Acid – 5 mg

Brand:
Cayman
CAS:
52809-07-1
Storage:
-20
UN-No:
Non-Hazardous - /

L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; Ki = 6.43 nM).{21635,24138,33255,33256,23341,33260} L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.{33257,33258}  

 

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Description

A natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as (GRIK4 (Ki = 6.43 nM)

Formal name: αS-amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid

Synonyms: 

Molecular weight: 189.1

CAS: 52809-07-1

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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